导语:
01
FH与2SC
02
FH缺陷与肿瘤
图1. FH缺失或突变致病机理
皮肤平滑肌瘤
子宫平滑肌瘤
肾细胞癌
03
FH与2SC在FH缺陷肿瘤中的诊断价值
迈新相关抗体
抗体名称 | 产品编号 | 克隆号 | 细胞定位 |
FH | MAB-1014 | J-13 | 胞质 |
2SC | RAB-1015 | 兔多抗 | 胞质/胞核 |
[1] 赵子辰, 王文慧, 冯凤芝. 遗传性平滑肌瘤病及肾细胞癌综合征研究进展[J]. 实用妇产科杂志, 2018, v.34(04):23-26.
[2] 张伟, 褚菁, 邹玉玮, et al. 延胡索酸水合酶缺陷型肾细胞癌的临床病理学特征[J]. 中华病理学杂志, 2019, 048(002):120-126
[3]Zyla Roman E,Hodgson Anjelica. Gene of the month: FH.[J]. Journal of clinical pathology,2021:1-5
[4]Pan X , Zhang M , Yao J , et al. Fumaratehydratase-deficient renal cell carcinoma: a clinicopathological and molecular study of 13 cases[J]. Journal of Clinical Pathology, 2019, 72(11):jclinpath-2019-205924.
[4] Miettinen M,Felisiak-Golabek A,Wasag B,et al. Fumarase-deficient uterine leiomyomas: an immunohistochemical,molecular genetic,and clinicopathologic study of 86 cases[J]. Am J Surg Pathol,2016,40( 12) : 1661-1669.
[5] Joseph N M, Solomon D A, Frizzell N, et al. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients[J]. American Journal of Surgical Pathology, 2015, 39(11):1529-1539.
[6] Chen Y B , Brannon A R , Toubaji A , et al. Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome–associated Renal Cancer: Recognition of the Syndrome by Pathologic Features and the Utility of Detecting Aberrant Succination by Immunohistochemistry[J]. The American Journal of Surgical Pathology, 2014, 38(5):627-637
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